t1am metabolites (3- iodothyroacetic acid, ta1; thyronamine, t0am; thyroacetic acid, ta0; n-acetyl-3- iodothyronamine; n-ac-t1am)  (Scanlan International Inc)

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: TA1 modifies learning, reduces nociceptive threshold and increases plasma glucose in mice. Mice (n = 20 for each groups of animals) were injected i.c.v. with TA1 (0.4, 1.32 or 4 μg·kg−1 or with Veh and, after 15 min, were assessed by the passive avoidance paradigm (A) or their nociceptive threshold measured by the the hot plate test (B). **P < 0.01, ***P < 0.001 versus Veh. Plasma glucose was also measured 15 min after TA1 injection, in blood collected from the tail veins of 4 h starved mice (n = 10 for r each groups of animals). Results are expressed as means ± SEM; *P < 0.05 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Clinical Proteomics, Injection, Hot Plate Test

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: The effects of histamine H1 and H2 receptor antagonists on TA1-induced modification of learning, pain threshold and plasma glucose in mice. Mice (n = 20 for each groups of animals) were pretreated s.c. with a single injection of pyrilamine (10 mg·kg−1) or zolantidine [5 mg·kg−1, 15 min before the i.c.v. injection of T1A (0.4, 1.32 and 4 μg·kg−1) or Veh.]. 15 min after TA1 or Veh injection, mice were assessed by the passive avoidance paradigm (A), or nociceptive thresholds determined by the hot plate test (B). Plasma glucose was also measured 15 min after TA1 (0.4, 1.32 and 4 μg·kg−1) i.c.v. injection in the blood collected from the tail veins of 4 h starved mice (n = 10 for each treatment) (C). Results are expressed as means ± SEM. *P < 0.05, **P < 0.01,***P < 0.001 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Modification, Clinical Proteomics, Injection, Hot Plate Test

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: TA1 reversed scopolamine-induced amnesia. TA1, 1.32 and 4 μg·kg−1 (n = 10 for each dose) or Veh were injected i.c.v. in mice (n = 20 for each groups of animals) pretreated i.p. with scopolamine (0.3 mg·kg−1, n = 30) or saline. Mice were then assessed by the passive avoidance paradigm. Results are expressed as means ± SEM. §P < 0.05 and §§§P < 0.001 versus Veh. + scopolamine, ***P < 0.001 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Injection, Saline

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: T1A failed to induce hyperglycaemia and to raise plasma glucose when injected i.c.v. in HDC−/− mice. TA1 (1.32 and 4 μg·kg−1), or Veh, were injected i.c.v. in HDC+/+ and HDC−/− mice (n = 10 for each group of animals). After 15 min, nociceptive thresholds to a thermal stimulus and plasma glucose were evaluated in HDC+/+ (A and B) and in HDC−/− mice (C and D). Results are presented as the means ± SEM. *P < 0.05 versus Veh; **P < 0.01 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Clinical Proteomics, Injection